Interaction between adenosine compounds and norepinephrine in dog renal circulation.

HASRIMOTO, K. and KOKUBUN, H. Interaction between Adenosine Compounds and Norepinephrine in Dog Renal Circulation. Tohoku J. exp. Med., 1972, 107 (4), 373-380 -Drugs were administered to anesthetized dogs directly into the left renal artery perfused with animal's own blood at a constant pressure. A single injection of adenosine caused prompt renal vasoconstriction, while an infusion of adenosine caused initial vasoconstriction which recovered to the control level even though infusion was continued. The vasoconstriction caused by a single injection of adenosine was not only depressed but also reverted to vasodilation during infusion of adenosine in its concentration from 8•~10-9 to 8•~10-6g/ml in the perfused blood (self-inhibition), while norepinephrine-induced vasoconstriction was significantly enhanced in the concentration as low as 3•~ 10-9g/ml of adenosine. The vasoconstriction caused by stimulation of renal